Protein Details: ATP-sensitive inward rectifier potassium channel 15

Protein ID

ICDB_Pro_0281

Protein Name

ATP-sensitive inward rectifier potassium channel 15

Gene Name

Kcnj15

Organism

Mus musculus (Mouse)

Length

375 amino acids

AlphaFoldDB

AF-O88932-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Sequence

MDAIHLGMSSAPLVKHTNGVGLKAHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVVYYAIAFIHGDLQLGESNSNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVISKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQKLEEQYRQEDQRERELRSLLLQQSNV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the proximal segment of the nephron.

DOI ID

10.1016/s0925-4773(00)00364-6; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1681/asn.2020111587

RefSeq

NP_001034145.1; NP_001258618.1; NP_001258620.1; NP_001258622.1; NP_001258624.1; NP_062638.1; XP_006523014.1; XP_006523015.1; XP_017172374.1